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Dechallenge and Rechallenge refer to a drug being stopped and restarted in a patient,respectively. A positive dechallenge has occurred, for example, when an adverse event abates or resolves completely following the drug's discontinuation.
A positive rechallenge has occurred when the adverse event re-occurs after the drug is restarted. Dechallenge and rechallenge play an important role in determining whether a causal relationship between an event and a drug exists. Event refers an adverse event. Harm is the nature and extent of the actual damage that could be caused.
Implied causality refers to spontaneously-reported AE cases where the causality is always presumed to be positive unless the reporter states otherwise. Life-threatening refers to an adverse event that places a patient at the immediate risk of death. Phase refers to the four phases of development: I - small safety trials early on in a drug's development; II - medium-sized trials for both safety and efficacy; III - large trials, which includes key or so-called "pivotal" trials; IV - large, post-marketing trials, typically for safety reasons.
There are also intermediate phases designated by an "a" or "b", e. Phase 2b. Risk factor is an attribute of a patient that may predispose, or increase the risk, of that patient developing an event that may or may not be drug-related. For instance, obesity is considered a risk factor for a number of different diseases and, potentially, ADRs. Signal is a new safety finding within safety data that requires further investigation.
Ladish While love is love no matter what, some prefer to date within their own race, ethnicity and even religious or political views. Today there are dating sites for yogis, doctors, lawyers, pet lovers, and of course, Latinos or Hispanics. Many sites come and go, but here are five that have been around for a while and that have different offerings depending on what you are looking for, whether it is a friend or a more lasting relationship—even marriage.
All of them have a free feature which allows you to check out the scene, and all of them have paid subscriptions that you can find out about once you become a registered user. It is built around the mission of making connections.
The site provides safety tips for online dating to make sure you are not being scammed instead of courted. It is owned by PeopleMedia, a Match. You can browse for free, but there is a fee if you sign up to interact. You can register online and then in your profile select that you prefer to date Hispanic men or women, and eHarmony will factor that in when choosing your matches.
In addition to having your profile online for potential suitors to browse you can also host your own blog on it. There are a number of good reviews about the site online. Many users seem to enjoy the blogging option and the fact that there are several ways to meet your match.